Notice: This lecture is a research seminar for credit.

Time

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Mar 22, 2019 9:30-10:30 a.m.

Abstract

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Inthis collaborative study, we addressed how endogenous glucagon like peptide-1(GLP-1) signaling functions in the hypothalamus. By utilizing a novel Gcg(encodes GLP-1)-Cre mouse model combined with both ChR2-assisted circuit mapping (CRACM)and retrograde rabies virus tracing strategies, we mapped the projection fromthe brain stem nucleus tractussolitaries (NTS) to the hypothalamus. We present strong evidence that therelease of endogenous GLP-1 in these pathways is sufficient and necessary forthe suppression of food intake behavior. Using interdisciplinary methodologyincluding synaptic physiology in brain slices, genetic identification ofneuronal subtypes and in vitro biochemistry, we uncovered the molecularsignaling cascade for GLP-1 function in the brain, by which it enhancesexcitatory synaptic strength to mediate anorexia via both pre- and postsynapticreceptors. 

Speaker's Bio

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2007.9-2012.6 PhD. ofNeuroscience, University of Science and Technology of China, Hefei, China;

2008.10-2013.6 PhD. of Medicine,University of Amsterdam, Amsterdam, The Netherlands;

2013.5-2014.8 Postdoc Fellow,Molecular Biology, Mayo Clinic, Rochester, The United States;

2014.9-2018.5 Postdoc Fellow,Neurobiology and Cell Biology, Rutgers, New Brunswick, USA;

2018.5-2019.3 Research Associate,Neurobiology and Cell Biology, Rutgers, New Brunswick, USA;

Registration

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Professors and students of TBSI are welcometo attend. The lecture is also open to the public. For off-campuspersonnel, please scan the QR code and and fill in your information (name,company, contact number, ID number). The language of the lecture isEnglish.