EDUCATION
2006.9 – 2010.3, Ph.D., Molecular Medicine, University of Auckland, New Zealand (NZ). Thesis title: ‘Secreted oncogenes in human endometrial carcinoma’.
2000.6 – 2003.5, M.Sc., Microbiology, University of Pune, India. Dissertation title: ‘Enhancement, optimization and purification of b-galactosidase from Aureobasidium pullulans’, University of Pune, India
1996.6 – 1999.5, B.Sc., Microbiology, Sardar Patel University, India
PROFESSIONAL EXPERIENCE
2019.5-present Assistant Professor, Tsinghua-Berkeley Shenzhen Institute (TBSI). Shenzhen, The People's Republic of China
2018.1-2019.4 Senior Scientist, TBSI, Shenzhen, The People's Republic of China
2010.8- 2017.12 Research fellow; Advisor: Prof. Peter E. Lobie. Cancer Science Institute of Singapore, NUS, Singapore
2009.9-2010.8 Postdoctoral fellow; Advisor: Prof. Paul B. Fisher. Department of Human & Molecular Genetics, Virginia Commonwealth University (VCU), Virginia, USA
2004.6-2006.6 Research associate; Advisor: Prof. T. S. Sridhar. Triesta Sciences (I) Pvt. Ltd, Member of Healthcare Global (HCG) Enterprises Ltd, Bengaluru, India
2003.6-2004.5 Research associate, Advisor: Prof. Mario Vaz. St. John’s Research Institute, Bengaluru, India
RESEARCH INTERESTS
1. Identification and validation of new molecular targets in human malignancies
2. Biology of stem-like cancer cell- to tumour recurrence, therapy resistance, and metastasis
3. Translational research- development of inhibitory technologies
AWARDS & SCHOLARSHIP
2009 Postdoctoral Fellowship, Dept. of Human & Molecular Genetics, VCU, USA
2009 Travel Award, 21st Lorne Cancer Conference, Lorne, Australia
2007, 2008, 2009 Travel Award, National Research Centre for Growth and Development (NRCGD), NZ
2006 International Doctoral Scholarship, NRCGD, NZ
PATENTS
1. Title: Compounds as modulator of JAK-STAT pathway, methods, and applications thereof (co-inventor) US Patent number 9604974, Application number 15/004,114 (Industry Liaison Office (ILO) NUS Ref: 15042N-US
2. Title: Adamantyl-tethered thiazolyl-pyrazolines, methods and applications thereof (co-inventor), Indian complete patent application No. 201641024910 (ILO NUS Ref: 2016-239-01)
3. Title: Compounds (co-inventor) application number PCT/SG2018/050194, NUS, ILO Ref: 15044N-UK/PRV.
4. Title: Compounds As Inhibitors of Tff3 Dimerization, Methods and Applications Thereof (co-inventor) Singapore provisional application number 10201704579V. ILO, NUS Ref: 2016-238-01.
PROFESSIONAL ASSOCIATION
The Endocrine Society (Membership ID: 286274)
American Association for Cancer Research (Membership ID: 373456)
Review Editor in peer-review journals
BMC cancer
Cancer Molecular Targets and Therapeutics (Frontiers community)
Pharmacological Research (Elsevier)
RECENT PUBLICATION
1. Pandey V, Wu Z-S, Zhang M, Li R, Zhang J, Zhu T and Lobie PE. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma. Breast Cancer Research. 2014; 16(5):429.
2. Lau W-H, Pandey V, Kong X, Wang X-N, Wu Z, Zhu T and Lobie PE. Trefoil factor-3 (TFF3) stimulates de novo angiogenesis in mammary carcinoma both directly and indirectly via IL-8/CXCR2. PloS One. 2015; 10(11):e0141947.
3. Wang X-N, Wang S-J, #Pandey V, Chen P, Li Q, Wu Z-S, Wu Q and Lobie PE. Trefoil Factor 3 as a Novel Biomarker to Distinguish Between Adenocarcinoma and Squamous Cell Carcinoma. Medicine. 2015; 94(20).
4. Kong X, Wu W, Yuan Y, Pandey V, Wu Z, Lu X, Zhang W, Chen Y, Wu M and Zhang M. Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. Oncotarget. 2016; 7(20):29465.
5. Loo SY, Hirpara JL, Pandey V, Tan TZ, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S and Clément M-V. Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma. Antioxidants & Redox Signaling. 2016; 25(6):283-299.
6. Sebastian A, #Pandey V, Mohan CD, Chia YT, Rangappa S, Mathai J, Baburajeev C, Paricharak S, Mervin LH Bulusu KC, Fuchs JE, Bender A, Yamada S, Basappa, Lobie PE and Rangappa KS. Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer. ACS Omega. 2016; 1(6):1412-1424.
7. Ding K, Yuan Y, Chong Q-Y, Yang Y, Li R, Li X, Kong X, Qian P, Xiong Z, Pandey V. Ma L, Wu Z, Lobie PE, and Zhu T. Autocrine prolactin stimulates endometrial carcinoma growth and metastasis and reduces sensitivity to chemotherapy. Endocrinology. 2017. 10.1210/en.2016-1903.
8. You M, Chen Y, Chong Q, Wu M, Pandey V, Chen R, Liu L, Ma L, Wu Z and Zhu T. Trefoil factor 3 mediation of oncogenicity and chemoresistance in hepatocellular carcinoma is AKT-BCL-2 dependent. Oncotarget. 2017;10.18632/oncotarget.16950.
9. Chong QY, You ML, Pandey V, Banerjee A, Chen YJ, Poh HM, Zhang M, Zhu T, Ma L, Basappa S, Liu L, and Lobie PE. Release of HER2 repression of trefoil factor 3 (TFF3) expression mediates trastuzumab resistance in HER2+/ER+ breast cancer. Oncotarget 2017, 10.18632/oncotarget.18431.
10. Pandey V, Zhang M, Chong QY, Raquib AR, Mingliang Y, Pandey AK, Liu DX, Liu L, Ma L, Jha S, Wu ZS, Zhu T, and Lobie PE. Hypomethylation associated activation of TFF3 mediates tamoxifen-stimulated oncogenicity of endometrial carcinoma cells. Oncotarget. 2017 Aug 24;8(44):77268-77291. doi: 10.18632/oncotarget.20461.
11. Chen YJ, You ML, Chong QY, Pandey V, Zhuang QS, Ma L, Zhu T, Lobie PE. Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behaviors of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of Claudin-1 Expression. International Journal of Molecular Sciences, 2017 Jun; 18(6): 1274.
12. Wang JJ, Chong QY, Sun XB, You ML, Pandey V, Chen YJ, Zhuang QS, Liu DX, Ma L, Wu ZS, Zhu T, Lobie PE. Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma. Oncotarget 2017 Oct 10;8(61):103900-103918.
13. Bui NL, Pandey V, Zhu T, Ma L, Basappa, Lobie PE. Bad phosphorylation as a target of inhibition in oncology. Cancer Letters. 2018 Feb 28; 415:177-186.
14. Pandey V, Wang B, Mohan CD, Raquib AR, Srinivasa V, Rangappa S, Fuchs JE, Girish KS, Zhu T, Bender A, Yin X, Ma L, Basappa, Rangappa KS, and Lobie PE. Discovery of a novel small molecule inhibitor of specific serine-residue BAD phosphorylation. Proceedings of The National Academy of Sciences (PNAS) 2018 Oct 11. pii: 201804897. doi: 10.1073/pnas.1804897115.
15. Pandey V, Zhang M, Mingliang Y, Chen R, Wu ZS, Zhu T, Xu XQ, and Lobie PE. Expression of two genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cells. Cell Death and Disease, 2018, volume 9(12), P: 1147; DOI: 10.1038/s41419-018-1177-6.
