Research area: Biofabrication
Research expertise and interests:
1. Biofabrication and Bio-3D Printing
2. Computer-Aided Tissue Engineering
3. CAD/CAM and Additive Manufacturing
Description of research:
Professor Wei Sun mainly engaged in basic and applied research in the field of leading international biological manufacturing and biological 3D printing related cross frontier, and exploring cross innovation in modern engineering and manufacturing science materials, information, biology, and medicine in many disciplines. Main research includes cell/organ 3D printing and in vitro biological function structure system building, bionic design and manufacturing, regenerative medicine model, biological/pathological/pharmacological model and new medicine detection model, cells/tissues/organs chip manufacturing based on cell, biological machinery equipment and living systems manufacturing, research and manufacturing of advanced biological manufacturing equipment.
Professor Wei Sun gets scientific research funding from U.S. National Science Foundation (NSF), U.S. National Aeronautics and Space Administration (NASA), U.S. Federal Aviation Administration (FAA), U.S. department of defense (DoD), U.S. army research institute (ARL) and Johnson & Johnson. In charge of projects from natural science foundation of China, 863 plan project, national major projects for new drug research and development, pilot plan pre-research of space science research center, academy of sciences, more than 10 projects from the country and enterprises. In 2014, Professor Sun led Tsinghua team to build in vitro 3D tumor models for the first time with the application of 3D printing technology, and it was interviewed and broadcasted by BBC, also reported by more than 50 Medias. In 2016, 3D printing of embryonic stem cells technology of the team was honored by SOHU as one of the five progresses in 3D printing technology. Altogether, Professor Sun has published more than 450 papers and meeting abstracts, more than 250 times of invited special reports, and more than 50 patents.
Courses to be offered: Introduction to Computer Aided Tissue Engineering (32 credit hours, in English)
Education background:
Ph.D. in Mechanical Engineering, 1992, Drexel University, Philadelphia, USA
M.S. in Mechanical Engineering, 1988, Drexel University, Philadelphia, USA
M.S. in Solid Mechanics, 1984, Hefei University of Technology, Hefei, China
B.S. in Solid Mechanics, 1984, Hefei University of Technology, Hefei, China
Professional experiences:
Department of Mechanical Engineering, Tsinghua University, China, Professor, 2010-Present
Drexel University, Albert Soffa Chair Professor, 2008-Present
Drexel University, Professor, 2007-2008
Drexel University, Associate Professor, 2003-2007
Drexel University, Assistant Professor, 1998-2003
Administrative appointments:
09/2008 - present, Albert Soffa Chair Professor of Mechanical Engineering, Drexel University
07/2010 - present, Director, Biomanufacturing Engineering Research Center, Tsinghua University
07/2013 -present, Director, Biofabrication and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, China
01/2012-present, Director, Biomanufacturing Engineering Laboratory, Tsinghua Shenzhen Graduate School, Shenzhen, China
2010-Present, President, International Society of Biofabrication
2013-present, Vice President, International Society of Imaging Science and Technology
2006-2009, Founding Chair, Biomanufacturing Technical Committee, ASME
2009–Present, Editor-in-Chief, Biofabrication (published by IOP, IF=4.302,)
Editorial Board Members: Rapid Prototyping Journal, and other 6 Journals
Technical reviewer for Science, Nature and other 47 international journals
Proposal Reviewer and Panelist for: NSF, NIH, NSFC, EU, Singapore et al
Honors and awards:
Editor-in-Chief, Biofabrication (published by IOP: Institute of Physics, 2009-present)
Vice President, International Society of Imaging Science and Technology – IS&T (2013-2015)
Theme Thrust Chair on Biofabrication, Tissue Engineering and Regenerative Medicine International Society - TERMIS (2012-2015)
Founding President, International Society of Biofabrication (2010-2014)
Founding Chair, Biomanufacturing Technical Committee, Division of Manufacturing Science and Engineering, American Society of Mechanical Engineering (Founding Chair, 2006-2009)
Outstanding Research Award, College of Engineering, Drexel University (2009)
William Mong Fellow Award, the University of Hong Kong (September, 2008)
Outstanding Contribution to Graduate Teaching Award, Mechanical Engineering, Drexel, 2004
Ralph R. Teetor Educational Award, International Society for Automotive Engineers, 2003
Professor of the Year Award, Department of Mechanical Engineering, Drexel University, 2002
Highly Commend Award for Outstanding Paper, Literati Club, Emerald Publishing, 2001 & 2006
Publications:
a. Books
1.Forgacs, G. and Sun, W., Biofabrication: Micro- and Nano-Fabrication, Printing, Pattering, and Assemblies; Elsevier, William Andrew Applied science Publishers, 2013, ISBN: 978-1-4557-2852-7.
2.Hamid, Q. and Sun, W., “Additive Fabrication of Cell-laden Microfluidic Devices”, Scholars’ Press, 2015, ISBN-13: 978-3639662207, ISBN-10: 3639662202.
3.Chang, R. and Sun, W., “Biofabrication of three-dimensional liver cell-embedded tissue constructs for in vitro drug metabolism models”, LAP Lambert Academic Publishing, 2009, ISBN: 978-3-8383-2150-9.
4.Nair, K., Yan, K. and Sun, W., “Multi-scale computational modeling and characterization of bioprinted tissue scaffolds”, VDM Verlag Publishing House Ltd, 2009; ISBN-13: 978-3-6390-9907-2.
5.Starly, B. and Sun, W., “Biomimetic Design and Fabrication of Tissue Engineered Scaffolds”, VDM Verlag Publishing House Ltd, 2007, ISBN: 978-3-8364-2464-6
b. Selected referred papers
1.Ouyang L, Highley CB, Sun W, Burdick JA, A Generalizable Strategy for the 3D Printing of Hydrogels from Non-viscous Photocrosslinkable Inks, Advanced Materials, 2017, DOI: 10.1002
2.Zhao, L., Chang Y., Yao, R., Lin, F. and Sun, W., Modeling on Micro-droplet Formation for Cell Printing Based on Alternating Viscous-Inertial Force Jetting. Journal of Manufacturing Science and Engineering, 2016, ISSN: 1087-1357; DOI: http://dx.doi.org/10.1115/1.4032768
3.Mi, Shengli, Du, Zhichang, Xu, Yuanyuan, Wu, Zhengjie, Qian, Xiang, Zhang, Min, and Sun, Wei, , “Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening at different cell proportions”, Scientific Reports, 2016， | 6:35544 | DOI: 10.1038
4.Wu, Z., Su, X., Xu, Y., Kong, B., Sun, W. and Mi, S., “Bioprinting three-dimensional cell-laden tissue constructs with controllable degradation. Scientific Reports, 2016 | 6:24474 | DOI: 10.1038
5.Ouyang, Liliang; Yao, Rui; Zhao, Yu; Sun, Wei, “Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells' Biofabrication 2016; 8(3): 035020: doi: 10.1088/1758-5090/8/3/035020
6.Liu, Y., Hamid, Q., Synder, J., Wang, CY and Sun. W., “Evaluating fabrication feasibility and biomedical application potential of in situ 3D printing technology”, Rapid Prototyping Journal, 2016, Volume 22 Issue 6, pp. 947-955
7.Snyder JE, Son AR, Hamid Q, Sun W. Hetero-cellular Prototyping by Synchronized Multi Material Bioprinting for Rotary Cell Culture. Biofabrication 8 (2016) 015002
8.Snyder, J., Son, AR., Hamid, Q. and Sun, W., “Fabrication of Microfluidic Manifold by Precision Extrusion Deposition and Replica Molding for Cell laden Device”, ASME Transaction: Journal of Manufacturing Science and Engineering, APRIL 2016, Vol. 138 / 041007
9.Jia, S., Zhang, T., Pan, W., Liu, J., Xiong, Z. and Sun, W., “In vivo Evaluation of a Novel Oriented Scaffold- BMSC Construct for Enhancing Full-thickness Articular Cartilage Repair in a Rabbit Model”, PLOS ONE, | DOI:10.1371/journal.pone.0145667 , 2015
10.Ouyang L, Yao R, Mao S, Chen X, Na J, Sun W. Three-dimensional bioprinting of embryonic stem cells directs high-throughput and highly uniformed embryoid body formation. Biofabrication. 2015;7(4): 044101.
11.Zhao, Y., Li, Y., Mao, S., Sun, W., Yao, R.,The influence of printing parameters on cell survival rate and printability in microextrusion-based 3D cell printing technology, Biofabrication, 2015, 7(4), 045002.doi: 10.1088/1758-5090/7/4/045002
12.Snyder JE, Son AR, Hamid Q, Sun W. Mesenchymal Stem Cell Printing: “Survivability and Possible Phenotype Reprogramming”, Biofabrication 7 (2015) 044106
13.Zhao, Y., Li, Y., Mao, SS, Sun, W. and Yao, R., “The influence of printing parameters on cell survival rate and printability in microextrusion-based 3D cell printing technology”, Biofabrication 7 (2015) 045002
14.Zhao, L., Chang Y., Yao, R., Lin, F. and Sun, W., “Alternating Force Based Drop-on-demand Micro-droplet Formation and 3D Deposition”, Journal of Manufacturing Science and Engineering, 2015;137(3):031009-031009-9. doi:10.1115/1.4029803
15.Ouyang, L., Yao, R., Chen, X., Na, J. and Sun, W., “3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions”, Biofabrication 7 (2015) 015010；doi:10.1088/1758-5090/7/1/015010
16.Zhao, H., Li, X., Zhao, S., Zeng, Y., Zhao, L., Ding, H., Sun, W. and Du, Y., “Microengineered in vitro Model of Cardiac Fibrosis through Modulating Myofibroblast Mechanotransduction”, Biofabrication 6 (2014) 045009, doi:10.1088/1758-5082/6/4/045009
17.Zhao, Y., Rui, Y., Ouyang, L., Ding, H., Zhang, T., Zhang, K., Cheng, S. and Sun, W. “Three-dimensional printing of Hela cells for cervical tumor model in vitro”, Biofabrication, 6(3), 2014, doi:10.1088/1758-5082/6/3/035001
18.Hamid, Q., Wang, C., Zhao, Y., Snyder, J. and Sun, W., “A three-dimensional cell-laden microfluidic chip for in vitro drug metabolism detection”, Biofabrication, 6(2), 2014, doi:10.1088/1758-5082/6/2/025008
19.Ringeisen, B., Pirlo, R., Wu, P., Boland, T., Huang, Y., Sun, W., Hamid, Q. and Chrisey, D., “Cell and organ printing turns 15: Diverse research to commercial transitions”, MRS Bulletin, 2013, 38, 834-843
20.Shor, L., Guceri, S., Wen, X., Gandhi, M. and Sun, W., “Fabrication and Cell-matrix Interaction Study on 3D Polycaprolactone/Hydroxypatite Tissue Scaffolds”, Biomaterials, 2007, 28(35), 5291-5297。
Patents:
1.一种移植用子宫颈仿生物及其制备方法, 孙伟, 庞媛, 姚睿。杨霞。申请号201610284350.4, 申请日20160504.
2.一种基于微流控芯片的打印喷头装置。弥胜利，孙伟，徐圆圆等。申请号：201510069086.8，申请日期：2015.02.09
3.一种冰胶支架及其制备方法和用途, 孙伟, 姚睿, 庞媛。申请号2015105904596, 申请日20150916
4.一种3D打印机的旋转喷头装置。孙伟、弥胜利、吴啸跃。专利号：ZL201510069102.3 授权时间：2015.02.10
5.微流控芯片、系统及其应用。孙伟、弥胜利、徐圆圆、吴啸跃。专利号：ZL201510221090.1 授权时间：2015.05.04
6.冰胶三维结构体、其制备方法及应用。申请中国专利，姚睿，孙伟，毛双双。申请号201510221917.9, 申请日2015.05.04。
7.一种用于组织、器官芯片集成制造的三维打印方法及装置。孙伟，赵雨，姚睿，李杨，申请号：2014510075517.1，申请时间：2015.02.12
8.用于细胞培养的微流控芯片，动态培养装置及方法。弥胜利，徐圆圆，孙伟等，申请号：201410559419.0，申请日期：2014.10.20
9.用于生物毒性检测的肺组织模型及生物毒性检测方法。姚睿，赵雨，孙伟，林峰，申请号：201410524951.9，申请日期：2014.10.08
10.生物材料三维成形设备及其挤出喷头。刘长勇，孙伟，林峰等，申请号：201310566068.1，申请日期：2013.11.13
11.“Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering”, Invertors: W. Sun and J. Nam; US Patent #: 9,427,496: Date: Aug. 30, 2016 (Priority date: Feb. 21, 2006)
12.“Layered manufacturing utilizing foam as a support and multifunctional material for the creation of parts and for tissue engineering”, Invertors: Wei Sun and Jae. Nam; US Patent #: 9,168,328, Oct. 27, 2015 (Priority date: Feb. 24, 2006)
13.“Integratable Assisted Cooling System For Precision Extrusion Deposition In The Fabrication Of 3D Scaffolds”, Inventors: Wei Sun and Qudus Hamid, US Patent #: 8,936,742, January 20, 2015
14.“Method for Making Artificial Scaffolds Having Porous Three-Dimensional Body Comprising Cells”, Invertors: A. Darling, L. Shor, W. Sun and S. Guceri; US Patent #: 8,735,117, May 27, 2014
15.“Method and Apparatus for Computer-Aided Tissue Engineering for Modeling, Design and Freeform Fabrication of Tissue Scaffolds, Constructs, and Devices”, Inventors: W. Sun, J. Nam, A. Darling and S. Khalil, US Patent #: 8,639,484, January 28, 2014
16.“Orthosis and Method of Use for Treatment and Rehabilitation of Dropfoot” Invertors: S. Siegler, Brett Hraban, Elizabeth LaMontagne, Joshua Meles and W. Sun; US Patent #: 8,500,668, August 6, 2013
17.“Micro Organ Device”, Invertors: Gonda, S., Chang, R, Starly, B., Culberson, C., Holtorf H., Sun, W., and. Leslie, J., US Patent #: 8,580,546, Nov. 12, 2013
18.“Micro Organ Device”, Invertors: Gonda, S., Chang, R, Starly, B., Culberson, C., Holtorf H., Sun, W., and. Leslie, J., US Patent #: 8,343,740, May 2, 2013
19.“Method for Fabricating Membrane Having Hydrophilicity and Hydrophobicity”, Invertors; LEE, KIM, SUN and HWANG; US Patent #: 8,372,297, Feb. 12, 2013; Japan: 2010-550599, Korea: KR: 10-2008-0024030
Research projects:
1.基于细胞精确受控组装体外仿生模型构建的基础研究（51235006），国家自然科学基金重点项目, 290万
2.复杂组织器官构建关键技术及产品研发（2012AA020506），国家863计划，632万元
3.建立基于iPS细胞及细胞3D打印模型药物筛选系统及成药性评价技术 （2015ZX09501009），2015重大新药创制国家科技重大专项， 195万
4.空间微生理系统的3D打印构建及应用, “十三五”空间科学先导专项预研项目，15万
5.111“生物制造和体外生命系统工程”交叉创新引智基地，教育部，2017， 450万
6.3D打印完全可降解锥形冠状动脉支架的研发与评价（Z150001），2016北京市自然科学基金重点课题， 50万
7.6mm以下小口径可降解仿生血管的研发（Z14110700020000），北京市科学技术委员会课题， 143万
8.异质细胞集成三维打印装备的开发及体外三维异质肿瘤模型的构建研究（Z141100002814003），北京市科学技术委员会，总经费：185.75万
9.深圳生物制造技术与应用工程实验室提升项目，深圳发改委，共300万。
10.基于微流控芯片技术3D癌症迁移模型的构建研究，深圳市基础研究项目，共50万
11.基于双网络交联水凝胶的3D打印生物墨水的研究，深圳市基础研究项目，共200万
Invited Presentations （from 2015）:
1.“From 3DP to Bio-3DP: Challenges and Opportunities”, Shenzhen Advanced Technology Institute, Chinese Academy of Sciences, December 16, 2016, as invited seminar speaker
2.“3D Bioprinting for in vitro Tissue Models”, SFB Pre-Conference Workshop on “Biomaterial Scaffolds for Tissue Engineering”, 2016 TERMIS AM San Diego, CA, USA, December 11, 2016, as invited workshop speaker
3.“3D Bioprinting for in vitro Tissue Models”, MRS 2016 Fall Meeting: The Symposium BM3 Biomaterials for Regenerative Medicine, Boston, MA, USA, November 28, 2016, as invited symposium speaker
4.“From 3D Printing to 3D Bioprinting – Challenges and Opportunities”, 2016 China-Korea, International Symposium on Bionic and Biomaterials for Regenerative Medicine, Chengdu, China, November 19, 2016, as invited symposium speaker
5.“From 3D Printing to 3D Bioprinting – Challenges and Opportunities”, Dept. of Industrial and Systems Engineering, Rutgers University, NJ, USA, 10/25, 2016, as invited seminar speaker
6.“From 3D Printing to 3D Bioprinting – Challenges and Opportunities”, 2017 NJ Biomaterials Science Symposium, Iselin, NJ, USA， October 24, 2016, as invited keynote Speaker
7.“3D Bioprinting – Challenges and Opportunities”, 2016 IPRC-Tsinghua Joint Symposium on Biofabrication, Busan, Korea, September 23, 2016, as invited keynote Speaker
8.“3D Bioprinting – Challenges and Opportunities”, Department of Chemical Engineering, National Tsing Hua University, Hsinchu City, Taiwan, 9/7, 2016, as invited seminar Speaker
9.“3D Bioprinting for Tissue Engineering – Challenges and Opportunities”, TERMIS-AP 2016, Tamsui, Taiwan, September 4, 2016, as invited Keynote Speaker
10.“3D Bioprinting – Challenges and Opportunities”, The First POSTECH-Catholic University Biomedical Eng. Institute Symposium, Seoul, Korea, 8/19, 2016, as invited Plenary Speaker
11.“3D Bioprinting of in vitro Biological Models for Drug and Disease Study”, Korea-China-USA Nano Forum 2016, Seoul, Korea, July 15, 2016, as invited Keynote Speaker
12.“3D Bioprinting – Challenges and Opportunities”, Organ-on-a-Chip World Congress & 3D-Culture 2016, Boston, USA, July 8, 2016, as invited Keynote Speaker
13.“Cell 3D Printing and Application”, Workshop on Precision Medicine and Medical Biomaterials, Ministry of Science and Technology, Shenzhen, China, April 28, 2016, as invited workshop speaker
14.“Cell 3D Printing and Application”, Workshop on 3D Printing; Xiehe Medical University, Beijing, China, April 27， 2016, as invited workshop speaker
15.“From 3DP to Bio-3DP: Challenges and Opportunities”, 2016 Design of Medical Devices Conference: Emerging Technology Forum 3D Printed Bionic and Medical Devices, University of Minnesota, Minneapolis, USA, April 14, 2016, as invited keynote speaker
16.“On Bio-3D Printing”, Tsinghua-Berkley Joint Research Symposium, Berkeley, CA, USA, April 11， 2016, as invited speaker
17.“Bio-3D Printing: Challenges and Opportunities”, 2016 Medical 3D Printing Summit, Changzhou, China, April 7， 2016, as invited keynote speaker
18.“Bio-3D Printing: Challenges and Opportunities”, NSF Additive Manufacturing for Health Workshop; The US National Science Foundation, Arlington, Virginia, USA, March 17, 2016, as invited workshop speaker
19.“Bio-3D Printing: Challenges and Opportunities”, Workshop for 3D Cell Printing for In Vitro Biological Model, Society for Technology in Anesthesia Annual Meeting, Palm Beach, Florida, USA, January 9, 2016, as invited workshop speaker
20.“Bio-3D Printing: Challenges and Opportunities”, International Workshop on Innovative Design and Process Modeling for Additive Manufacturing, Beijing University, Beijing, China, December 18, 2015, as invited workshop speaker
21.“Bio-3D Printing: Challenges and Opportunities”, 2015 Chinese Biomaterials Society Conference, Haikou, China, November 21, 2015, as invited symposium speaker
22.“3D Cell Printing In vitro Biological Models for Tissue Engineering”, Symposium on Biofabrication: 3D Printing of Regenerative Medical Implants, the 2015 TERMIS World Congress, Boston, MA, USA, September 10, 2015, as invited symposium speaker
23.“Effect of Bio-ink Viscosity and Printing Process on Cells”, Macromolecules & Interfaces Institute , Virginia Tech., Blacksburg, VA, USA, September 3, 2015, as invited MII/Fralin Visiting Scholar Lecture
24.“Printing in vitro biological model”, NSF/NIH-NCI Joint Workshop for “Integrative Additive Biomanufacturing and Tumor Engineering”, Bethesda, Maryland, USA, April 1, 2015, as invited panelist speaker
25.“3D Bioprinting: Challenges and Opportunities”, Institute of Process Engineering, China Academy of Sciences, Beijing, China, March 30, 2015, as invited seminar speaker
26.“Bio-3D Printing: Challenges and Opportunities”, Program for the Life Sciences Symposium, Florida State University, Tallahassee, Florida, USA, February 19, 2015, as invited speaker
27.“Bio-3D Printing: Challenges and Opportunities”, Stacking Layers Symposium, Florida State University, Tallahassee, Florida, USA, February 20, 2015, as invited speaker
