Research area: Biofabrication
Research expertise and interests:
· 3D Bioprinting
· Biofabrication
· Biomaterials
· Medical Devices
Courses to be offered:
1.Advanced Medical Device Design and Fabrication (2 credits, Graduate, Tsinghua University, China)
2.Soft Materials III: Fabrication of Biomaterials (2 credits, Graduate, Tsinghua Berkley Shenzhen Institute, China)
3.Engineering Analysis (3 credits, Undergraduate, University of Texas at El Paso, TX, USA, Fall or Spring semester)
4.Tissue Engineering (3 credits, Graduate, University of Texas at El Paso, TX, USA, Spring semester)
5.Advanced Engineering Mathematics (3 credits, Graduate, University of Texas at El Paso, TX, USA, Fall semester)
6.Mathematical Method for Mechanical Engineer (3 credits, Graduate, University of Texas at El Paso, TX, USA, Fall semester)
Education background:
2008, Postdoc, Wake Forest University, NC, USA, Regenerative Medicine
2005, Ph.D., Clemson University, SC, USA, Bioengineering
2000, M.S., China Institute of Atomic Energy, China, Radioimmunoassay
1994, B.S., Beijing University of Aeronautics and Astronautics, China, Polymeric Materials
Professional experiences:
2014-Present, Tsinghua University, China, Professor
2008-2013, University of Texas at El Paso, TX, USA, Assistant Professor
2010-2013, Texas Tech University, TX, USA, Adjunct Professor
2012-2013, Wake Forest University, NC, USA, Adjunct Professor
2005-2008, Wake Forest University, NC, USA, Research Scholar
2001-2005, Clemson University, SC, USA, Research Assistant
2000-2001, China Institute of Atomic Energy, Beijing, China, R&D Engineer
1994-1997, Institute of Fiber-reinforced Plastics, Chinese State Bureau of Building Materials, Beijing, China, R&D Engineer
Publications:
1.Dai X&, Liu L, Ouyang J, Li X, Zhang X, Lan Q, Xu T*. Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers Scientific Reports. 2017, 7(1):1457.
2.Lai K, Zhang J, Wang G, Luo X, Liu M, Zhang X, Yuan Y, Liu B, Xu T*. A biomimetic mesh for treating female stress urinary incontinence. Biofabrication, 2017, 9(1): 015008.
3.Dai XL, Ma C, Lan Q, Xu T*. 3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility. Biofabrication. (2016)
4.Sun BB, Wu T, He LP, Zhang JG, Yuan YY, Huang XJ, EI-Hamshary H, Al-Deyab SS, Xu T*, Mo XM*. Development of Dual Neurotrophins-Encapsulated Electrospun Nanofibrous Scaffolds for Peripheral Nerve Regeneration Binbin. Journal of Biomedical Nanotechnology, 2016, 12:1-14.
5.Deng KX，Ye X, Yang YY, Liu M, Ayyad A, Zhao YL, Yuan YY, Zhao JZ, Tao X*. Evaluation of efficacy and biocompatibility of a new absorbable synthetic substitute as a dural onlay graft in a large animal model, Neurological Research，2016, 1-10.
6.Lan Q*, Chen AL, Zhang T, Li GW, Zhu Q, Fan XM, Ma C, Xu T*. Development of 3D Printed Craniocerebral Models for Simulated Neurosurgery. World Neurosurgery, 2016, 91: 434-442.
7.Ding J, Deng M,Song XC,Chen C,Lai KL, Wang GS, Yuan YY, Xu T, Zhu L*. Nanofibrous biomimetic mesh can be used for pelvic reconstructive surgery a randomized study. Journal of the Mechanical Behavior of Biomedical Materials：2016, 61（1）: 26-35.
8.Groll J, Boland T, Blunk T, Burdick J, Cho DW, Dalton P, Derby B, Forgacs G, Li Q, Mironov V, Moroni L, Nakamura M, Shu WM, Takeuchi S, Vozzi G, Woodfield T, Xu T, Yoo J, Malda J. Biofabrication: Reappraising the definition in an evolving field. Biofabrication ，2016, 8（1）: 013001-013001
9.Shi ZD, Xu T, Yuan YY, Deng KX, Liu M, Ke YQ, Luo CY, Yuan T, Ayyad A.A New Absorbable Synthetic Substitute With Biomimetic Design for Dural Tissue Repair. Artificial Organs, 2016, 40(4):403-413
10.Xu T, Binder KW, Albanna MZ, Dice D, Zhao W, Yoo JJ, Atala A .“Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications”. Biofabrication. 5(1): 015001(2013).
11.Xu T, Zhao W, Zhu JM, Albanna MZ, Yoo JJ, Atala A. “Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology”. Biomaterials. 34(1):130-139(2013).
12.Rodríguez-Dévora JI, Ambure S, Shi ZD, Yuan YY, Wei S, Xu T*. “Physically facilitating drug-delivery systems”. Therapeutic Delivery. 3(1) :125-139(2012).
13.Rodríguez-Dévora JI, Zhang B, Reyna D, Shi ZD, Xu T*. “High throughput miniature drug-screening platform using bioprinting technology”. Biofabrication. 4(3)：035001(2012).
14.Rodríguez-Dévora1 JI, Shi ZD , Xu T*. “Direct assembling methodologies for high-throughput bioscreening”. Biotechnology Journal. 6(12):1454-1465(2011).
15.Zhao W, Xu T, Aboushwareb T, Atala A, Yoo J. “In vivo generation of functional tissues using the inkjet printing technology for reconstructive surgery”. Journal of The American College of Surgeons. 211(3):S87-S87 ( 2010).
16.Xu T, Baicu C, Aho M, Zile M, and Boland T. “Fabrication and characterization of bio-engineered cardiac pseudo tissues”. Biofabrication. 1(3): 1-6 (2009).
17.Xu T, Molnar P, Gregory C, Das D, et al.“Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel” . Biomaterials. 30(26): 4377-4383(2009).
18.Xu T, Rohozinski J, Zhao WX, Moorefield EC, Atala A, Yoo JJ. “Inkjet-mediated gene transfection into living cells combined with targeted delivery.” Tissue Engineering Part A. 15(1):95-101(2009).
19.Xu T, Olson J, Zhao WX, Atala A, Zhu JM, Yoo JJ. “Characterization of cell constructs generated with inkjet printing technology using in vivo magnetic resonance imaging”. Journal of Manufacturing Science and Engineering. 130 (2): 1-7 (2008).
20.Xu T, Kincaid H, Atala A, Yoo JJ “High-throughput production of single cell microparticles using an inkjet printing technology”. Journal of Manufacturing Science and Engineering. 130 (2):1-5(2008).
21.Xu T, Hipp J, Atala A, Yoo JJ, Van Dyke ME. “Genomic guided ECM biomaterials development for regenerative medicine applications”. Tissue Engineering Part A. 14(5): 739-739 (2008).
22.Xu T, Yoo JJ. “Inkjet gene printing: A novel approach to achieve gene modified cells for tissue engineering”. Tissue Engineering Part A. 14(5): 869-870 (2008).
23.De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. “Isolation of amniotic stem cell lines with potential for Therapy”. Nature Biotechnology. 25(1):100-106 (2007).
24.Boland T, Xu T, Damon BJ, Manley B, Kesari P, Jalota S, Bhaduri S. “Drop-on-demand printing of cells and materials for designer tissue constructs”. Materials Science And Engineering C. 27(3): 372-376 (2007).
25.Xu T, Zhang N, Nichols HL, Shi DL, Wen XJ. “Modification of nanostructured materials for biomedical applications”. Materials Science And Engineering C. 27(3): 579-594 (2007).
26.Boland T, Xu T, Damon B, Cui X. “Application of inkjet printing to tissue engineering”. Biotechnology Journal. 1(9):910-917 (2006).
27.Xu T, Gregory CA, Molnar P, Cui X, Jalota S, Bhaduri SB, Boland T. “Viability and electrophysiology of neural cell structures generated by the inkjet printing method”. Biomaterials. 27(19):3580-3588 (2006).
28.Varghese D, Deshpande M, Xu T, Kesari P, Ohri S, Boland T. “Advances in tissue engineering: cell printing”. Journal of Thoracic and Cardiovascular Surgery. 129 (2): 470-472 (2005).
29.Xu T, Jin J, Gregory C, Hickman JJ*, Boland T*. “Inkjet printing of viable mammalian cells”. Biomaterials. 26(1): 93-99 (2005).
30.Xu T, Gregory C, Molnar P, Boland T. “Fabricating neural and cardiomyogenic stem cell structures by a novel rapid prototyping — the inkjet printing method”. Nanoscale Materials Science in Biology and Medicine. 845:15-19(2005).
31.Kesari P, Xu T, Boland T. “Layer-by-layer printing of cells and its application to tissue engineering”. Nanoscale Materials Science in Biology and Medicine. 845:111-117 (2005).
32.Roth EA, Xu T, Das M, Gregory C, Hickman JJ, Boland T*. “Inkjet printing for high-throughput cell patterning”. Biomaterials. 25 (17): 3707-3715 (2004).
33.Xu T, Petridou S, Lee EH, Roth E, Vyavahare N, Hickman JJ, Boland T*. “Construction of high-density bacterial colony arrays and patterns by the ink-jet method”. Biotechnology And Bioengineering”. 85 (1): 29–33 (2004).
34.Wu FB, Han SQ, Xu T, He YF. “Sensitive time-resolved fluoroimmunoassay for simultaneous detection of serum thyroid-stimulating hormone and total thyroxin with Eu and Sm as labels”. Analytical Biochemistry. 314(1): 87-96 (2003).
35.Xu T, Han Shiquan and Wang Yishan. “Study of covalent immobilization of bio-molecules in solid phase immunoassay”. Guowai Medical Science: Clinical Biochemistry and Medical Diagnosis. 21(5): 244 (2000) .
36.Wu D and Xu T. “Preparation of amino acid with high-temperature solid-state catalytic isotope exchange method”. Atomic Energy Science & Technology. 34: 175 (2000) .
37.Wu FB, Xu YY, Xu T, Wang YS, Han SQ. “Time-resolved fluorescence immunoassay of thyroxine in serum: Immobilized antigen approach”. Analytical Biochemistry . 276(2): 171-176 (1999).
Patents:
Owns 64 patent applications and 45 issued patents, including 6 issued US patents, 1 issued EU patent, 1 issued Japan patent, and 32 issued Chinese patents etc. Some cases are listed below:
INKJET PRINTING OF VIABLE CELLS, US 7,051,654；
TREATING DEFECTIVE DURA WITH SYNTHETIC ARTIFICIAL DURA SUBSTITUTE，US8795708
An artifical dural substitute with multi-functional layers. Chinese issued patent: ZL200910037736.5
Academic projects:
1.Xu T(PI): “The Application of 3D Printing Technology in Battlefield Injury Repair”. China Military, period: 2017-2020, about $4,500,000 (granted)
2.Xu T(PI): “National High Technology Research and Development Program: Cell Bioprinting Project”. China Ministry of Science & Technology, Award# 2015AA020303, period: 01/01/2015-12/31/2017, about $2,000,000.
3.Xu T(PI): “Industrialization of Artificial Dural Substitute”, China Guangdong Province Government, Award#2013498C, Period: 01/012013-12/31/2015，about $400,000.
4.Xu T(co-PI): “Development of Tissue Regeneration and Repair Technologies”, China Shenzhen City Government. Period: 01/01/2013-12/31/207，about $2,400,000 (PI: Wei Sun).
5.Xu T(co-PI): “Guangdong Innovative Research Team Program”, China Guangdong Province Government. Period: 01/01/2012-12/31/206，about $4,800,000 (PI: Wei Sun)。
6.Xu T (PI): “SCORE: Bio-printing Stem Cell Based and Oxygen Releasing Tissue Grafts for Myocardial Infarction Repair”. U.S. National Institutes of Health (National Heart, Lung, and Blood Institute), Award #1SC2HL107235-01, period: 08/01/2010 – 04/30/2013, $423,289.
7.Xu T (PI): “Collaborative Research: Fluid Dynamics Foundations of Cell Printing”. U.S. National Science Foundation (NSF), Award # CBET0936236/38, Period: 09/01/2009-08/31/2012), $400.008 (In collaboration with Rui Qiao, Clemson University).
8.Xu T(PI): “Autologous Stem Cell Based and Oxygen Releasing Bio-printed Tissue Grafts for Myocardial Infarct Repair.” University of Texas System Research Institute. Award# 1464857451. Period: 01/2009-12/2009
9.Xu T (Co-PI), “Special Focus Competition: Graduate Programs at Institutions Serving Hispanic Americans”. U.S. Department of Education, $300,000. Period: 2009-2011. Role: Co-PI. (PI: Schoephoerster, Richard, UTEP)
10.Xu T(Co-PI):“In-situ Bio-Printing of Skin for Battlefield Burn Injuries”. U.S. Department of Defense. Award # AFIRM-W81XWH-08-2-32-YSKIN. Period: 2008-2013. $1,000,000 (PI: Yoo J, Wake Forest)
